Development, validation and routine use of a method for the determination of carbonyl compounds in cigar smoke

Development, validation and routine use of a method for the determination of carbonyl compounds in cigar smoke

The U.S. Food and Drug Administration recently finalized a rule that extends its regulatory authority to all tobacco products including cigars. This change could require the routine reporting of compounds of concern in cigar smoke including carbonyl compounds. There is currently no accepted method for the analysis of carbonyl compounds in mainstream cigar smoke. CORESTA Recommended Method (CRM) No. 74 has been found to be suitable for the analysis of carbonyl compounds in mainstream cigarette smoke and we investigated this method to determine if it could be expanded to include carbonyl compounds in mainstream cigar smoke. In the development of this method, we evaluated sample collection using the CORESTA cigar smoking conditions given in CRM 64. Method performance was verified for the stability of the trapped hydrazine during sample collection, trapping efficiency and accuracy of the method. With a few modifications to CRM 74, we were able to develop a fit for purpose method to determine carbonyl compounds in mainstream cigar smoke. This included a range of cigars including both flavored and unflavored products. We will report a summary of the method development, method validation and long-term method process control samples.

Authors and affiliations:
GILLMAN I.G.; MAINES J.H.; JABLONSKI J.J.
Enthalpy Analytical, Inc., Richmond, VA, U.S.A.

Citation:
CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 06