Cigarette Smoke & Filler2022-01-21T11:08:03-05:00

Smoke & Filler


Enthalpy offers a range of test methods for the collection and analysis of harmful and potentially harmful constituents (HPHCs) in tobacco, mainstream smoke (MSS), and side stream smoke (SSS). Methods include the analysis of tar, nicotine, carbon monoxide (TNCO) and the list of “Hoffmann analytes,” as well as the full list of 93 FDA HPHCs.

Enthalpy operates three smoke labs between the Richmond and Durham laboratories, allowing for redundancy and flexibility in our testing processes. Environmental conditions in our smoke labs are maintained to exacting specifications for humidity and temperature control using custom environmental control systems. Equipment within the lab is supported by emergency backup generators and uninterruptible power sources (UPS). Enthalpy houses quality-controlled facilities for conditioned storage and sample preparation. Dedicated freezers and refrigerators are available for segregated storage of samples and analytical standards. All laboratory data collected from smoking machine runs and analytical system outputs are stored on a secure, access-limited network with firewall and intrusion protection systems.

The science of analyzing tobacco products poses many unique challenges. These are highly complex matrices from which to generate samples suitable for instrumental analysis. The process of creating these samples requires the development and implementation of cutting-edge techniques to manipulate both cigarettes and smokeless tobacco products.

Our project scientists’ thorough knowledge of FDA HPHCs in tobacco and smoke has allowed for quick and robust method transfer to cigar and pipe tobacco to meet the requirements of the FDA’s Deeming Regulations for cigar and pipe products published May 10, 2016.

Researchers from Enthalpy utilize nationally and internationally accepted test methods – enhanced and adapted for our laboratories – to deliver consistent, high-quality data. Each HPHC project we conduct is generated under our rigorous ISO 17025 quality system, meaning the procedures used to generate your data are reliable and will stand up to scrutiny from inside and outside your organization. In addition to HPHC testing, we also have methods in place for routine product testing, including methods for product moisture, menthol, cigarette physical properties, and certification of lowered ignition propensity (LIP) testing.

  • Health Canada
  • ANVISA (Brazil)
  • FDA (USA) 2012 Abbreviated HPHC Testing
  • FDA (USA) Substantial Equivalence SE Testing
  • Ignition Propensity (LIP) – ASTM Method E2187-09, ISO Standard 12863


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